It is not known whether torsemide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. Ask your healthcare professional how you should dispose of any medicine you do not use. Following oral administration, peak plasma concentrations achieved within 1 hour. Administer orally without regard to meals.
Increases in plasma triglyceride concentrations reported. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. To prevent hypokalemia and metabolic alkalosis, use an aldosterone antagonist or potassium-sparing drug with Demadex in patients with hepatic disease.
Forbes AM. Halothane, adrenaline and cardiac arrest. Symptoms may include fast or irregular heartbeat; inability to urinate; nausea; severe headache; vomiting. Keep out of the reach of children. About FAERS: The FDA Adverse Event Reporting System FAERS is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Reporting of adverse events is a voluntary process, and not every report is sent to FDA and entered into FAERS. You may take torsemide with or without food.
Torsemide does not affect the protein binding of glyburide or warfarin. MacCosbe PE, Toomey K. Interaction of phenytoin and folic acid. Johnstone M. Adrenaline and noradrenaline during anaesthesia. Urinary excretion accounts for approximately 20% of total clearance in patients with normal renal function. 1 12 Most renal clearance occurs via active secretion of the drug by the proximal tubules into tubular urine.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Known hypersensitivity to torsemide or to sulfonylureas. This medicine will not cure your high blood pressure but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems, such as heart failure, blood vessel disease, stroke, or kidney disease. Weiner N. Norepinephrine, epinephrine, and the sympathomimetic amines. In Gilman AG, Goodman LS, Rall TW, Murad F, eds. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: MacMillan Publishing Company. 1985. Is bumetanide available as a generic drug? In patients with hepatic cirrhosis, renal clearance but not total clearance and half-life are increased. Check your regularly while taking this medication. Learn how to monitor your own pressure at home, and share the results with your doctor. Some MEDICINES MAY INTERACT with Demadex. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Torsemide is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Store Demadex at room temperature, between 59 and 86 degrees F 15 and 30 degrees C. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Demadex out of the reach of children and away from pets. Most renal clearance of torsemide occurs via active secretion of the drug by the proximal tubules into tubular urine. Tea Tree just saved me a trip to the Dr. I had Surgery on Cyst. Dr told me not to cover it. It became seriously infected so I had to bandage it and it became inflamed with pus coming out into the bandage. Remembered I had Tea Tree Oil. Applied Pure Tea Tree liberally to the deep wound. Impaired effectiveness and possible delayed excretion of loop diuretics may occur in patients with severe renal dysfunction. These individuals may require high dosages that are associated with an increased risk of electrolyte abnormalities hyponatremia, hypochloremic alkalosis, hypokalemia, hypomagnesemia, hypocalcemia and ototoxicity tinnitus, hearing loss. Therapy with loop diuretics should be administered cautiously in patients with significantly impaired renal function. Prolongation of the dosing intervals may be appropriate to prevent drug accumulation. The patient should be monitored closely for the signs and symptoms of fluid or electrolyte imbalance, including dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, arrhythmia, or gastrointestinal disturbances such as nausea and vomiting. Excessive diuresis should be avoided as it may induce dehydration and hypovolemia, which can result in an abrupt reduction in glomerular filtration and renal blood flow. If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, or if renal function becomes progressively worse as indicated by rising BUN or serum creatinine levels, an interruption or discontinuation of therapy should be considered.
Because Demadex and salicylates compete for secretion by renal tubules, patients receiving high doses of salicylates may experience salicylate toxicity when Demadex is concomitantly administered. Moderate. These medicines may cause some risk when taken together. Boehringer Mannheim. Demadex torsemide tablets and injection prescribing information. Rockville, MD: 1993 Oct. Associated Press American Diabetes Association. Diabetics urged: drop blood pressure. Chicago, IL; 2000 Aug 29. Press Release from web site. Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. condylox
WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider. Maximum of 200 mg as a single dose daily. Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. The changes subsided with chronic therapy. Rivey MP, Schottelius DD, Berg MJ. Phenytoin-folic acid: a review. Your condition may be treated with a combination of drugs. Use all medications as directed by your doctor. Do not change your doses or medication schedule without your doctor's advice. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Many patients who have high blood pressure will not notice any signs of the problem. In fact, most patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. In adults, initially, 20 mg once daily. 1 14 Increase as necessary by approximately doubling dosage until desired diuresis is attained. 1 14 Single doses exceeding 200 mg not adequately studied. This medicine may make you dizzy or drowsy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Sit or lie down if you feel dizzy. Stand up carefully. Safety and efficacy not established. Your doctor may have also prescribed a potassium supplement for you. If so, follow the dosing carefully. Do not start taking additional potassium on your own or change your diet to include more potassium without first checking with your doctor. Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. brand of adapalene adapalene
Some medical conditions may interact with dopamine. Katz RL, Katz GJ. Surgical infiltration of pressor drugs and their interaction with volatile anaesthetics. Demadex can be used alone or in combination with other antihypertensive agents. Demadex is not recommended for use in CHILDREN; safety and effectiveness have not been confirmed. Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests. DEMEDEX can increase the risk of renal toxicity related to administration of radiocontrast agents. National Heart, Lung, and Blood Institute National High Blood Pressure Education Program. The seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC 7. Bethesda, MD: National Institutes of Health; 2004 Aug. NIH publication No. 04-5230. Chronic use in hepatic disease not adequately studied. Demadex has been administered together with β-adrenergic blocking agents, ACE inhibitors, and calcium-channel blockers. Adverse drug interactions have not been observed, and special dosage adjustment has not been necessary. Loop diuretics increase the ototoxic potential of other ototoxic drugs, including aminoglycoside antibiotics and ethacrynic acid. This effect has been reported with concomitant use of torsemide and gentamycin. Avoid concomitant use of Demadex and aminoglycoside antibiotics, if possible. ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension ESH and of the European Society of Cardiology ESC. J Hypertens. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure JNC. Tinnitus and hearing loss usually reversible have been observed with loop diuretics, including Demadex. Higher than recommended doses, severe renal impairment, and hypoproteinemia, appear to increase the risk of ototoxicity. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. buy now online alfuzosin mastercard
Of the total number of patients who received Demadex in United States clinical studies, 24% were 65 or older while about 4% were 75 or older. No specific age-related differences in effectiveness or safety were observed between younger patients and elderly patients. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. Weber MA, Schiffrin EL, White WB et al. Clinical practice guidelines for the management of hypertension in the community: a statement by the American Society of Hypertension and the International Society of Hypertension. J Clin Hypertens Greenwich. United States and its territories. Indications, uses and warnings on Drugs. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. In patients with decompensated heart failure, hepatic and renal clearance are reduced, resulting in delivery of less drug to the intraluminal site of action and decreased natriuretic effect. 1 12 13 14 Total clearance is about half of that of healthy individuals; half-life and AUC increased.
This medicine may cause an increase in blood sugar levels. If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor. For direct IV injection, administer slowly over a period of 2 minutes. Demadex is to be used only by the patient for whom it is prescribed. Do not share it with other people. In healthy subjects, coadministration of torsemide was associated with significant reduction in the renal clearance of spironolactone, with corresponding increases in the AUC. However, the pharmacokinetic profile and diuretic activity of torsemide are not altered by spironolactone. Please refer to the for information on shortages of one or more of these preparations. Use and dose must be determined by your doctor. Coadministration of Demadex with ACE inhibitors or angiotensin receptor blockers can increase the risk of hypotension and renal impairment. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; chest pain; dizziness; irregular heartbeat; pain, redness, or swelling at the injection site; severe headache. Not known whether torsemide is distributed into milk. Torsemide is a white to off-white crystalline powder. zyban purchase payment canada
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Torsemide is a substrate of CYP2C9. Katz RL, Epstein RA. The interaction of anesthetic agents and adrenergic drugs to produce cardiac arrhythmias. Use Demadex as directed by your doctor. Check the label on the medicine for exact dosing instructions. What is bumetanide, and how does it work mechanism of action? Administer IV injections of torsemide either slowly over 2 minutes “bolus” or as a continuous infusion. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; chest pain; diarrhea; dry mouth or unusual thirst; fever, chills, or persistent sore throat; hearing loss or ringing in the ears; loss of appetite; muscle pain or cramps; rapid or irregular heartbeat; rectal bleeding; red, swollen, blistered, or peeling skin; restlessness; unusual bruising or bleeding; unusual tiredness or weakness; vomiting. Like other diuretics, torsemide reduces the renal clearance of lithium, inducing a high risk of lithium toxicity. Monitor lithium levels periodically when torsemide is coadministered. pemar.info synthroid
Overdose symptoms may include severe forms of some of the side effects listed in this medication guide. What should I avoid while taking Demadex torsemide? This list is not complete and many other drugs can interact with torsemide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you. This information should not be used to decide whether or not to take dopamine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dopamine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dopamine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dopamine. Furlanut M, Benetello P, Avogaro A, Dainese R. Effects of folic acid on phenytoin kinetics in healthy subjects. Sudden alterations of electrolyte balance in patients with cirrhosis may precipitate hepatic coma; use with caution in patients with hepatic cirrhosis and ascites. Demadex is contraindicated in patients with known hypersensitivity to Demadex or to povidone. Sympathomimetics can increase blood pressure and heart rate, which can increase the ability of anesthetics to change the rhythm of the heart. Numerous antihypertensive drugs, from a variety of pharmacologic classes and with different mechanisms of action, have been shown in randomized controlled trials to reduce cardiovascular morbidity and mortality, and it can be concluded that it is blood pressure reduction, and not some other pharmacologic property of the drugs, that is largely responsible for those benefits. The largest and most consistent cardiovascular outcome benefit has been a reduction in the risk of stroke, but reductions in myocardial infarction and cardiovascular mortality also have been seen regularly. Yuen GJ. Interaction of phenytoin and folic acid: an alternative explanation. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than one drug to achieve blood pressure goals. Importance of informing patients with diabetes mellitus that blood glucose concentrations may increase. If you have cirrhosis or other liver problems, your doctor may want to give your first dose of this medicine in a hospital or clinic setting to quickly treat any serious side effects that occur. Demadex is contraindicated in patients with hepatic coma. Because of its inhibition of CYP2C9 metabolism, torsemide may affect the efficacy and safety of sensitive CYP2C9 substrates, such as celecoxib, or of substrates with a narrow therapeutic range, such as warfarin or phenytoin. Monitor patients and adjust dosages if necessary. divalproex
In geriatric patients, decreased renal clearance. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day as directed. It is important to continue taking this medication even if you feel well. Most people with do not feel sick. Generally, it may take 4-6 weeks, and sometimes up to 12 weeks, before the full -lowering effect is seen. Do not stop taking this medication without consulting your doctor. Andersen N, Johansen SH. Incidence of catechol-amine-induced arrhythmias during halothane anesthesia. Note: No generic formulation of the following product is available. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal. You may develop an irregular heartbeat. In controlled studies in the United States, Demadex was administered to hypertensive patients at doses of 5 mg or 10 mg daily. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Demadex; it is not expected to harm a fetus. It is unknown if Demadex passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding. Adequate studies of Demadex have not been done in pregnant or breast-feeding women. Safety and effectiveness in pediatric patients has not been established for Demadex. Ikezono E, Yasuda K, Hattori Y. Effects of propranolol on epinephrine-induced arrhythmias during halothane anesthesia in man and cats. Demadex can cause potentially symptomatic hypokalemia, hyponatremia, hypomagnesemia, hypocalcemia, and hypochloremic alkalosis. Treatment with Demadex can cause an increase in blood glucose levels and hyperglycemia. Asymptomatic hyperuricemia can occur and gout may rarely be precipitated. Monitor serum electrolytes and blood glucose periodically.
Dopamine is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using dopamine at home, carefully follow the injection procedures taught to you by your health care provider. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Clinical pharmacology studies have confirmed this site of action in humans, and effects in other segments of the nephron have not been demonstrated. Diuretic activity thus correlates better with the rate of drug excretion in the urine than with the concentration in the blood. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. How should I take Demadex torsemide? Symptoms may include confusion; dizziness; dizziness or lightheadedness when sitting up or standing; dry mouth; excessive urination followed by a decrease in the amount of urine; muscle cramps or weakness; rapid or irregular heartbeat. Check with your doctor right away if you have a sudden decrease in hearing or loss of hearing. You may also have dizziness or ringing in the ears. Tell your doctor if you have a feeling of constant movement of self or surroundings or a sensation of spinning. Increases urinary excretion of sodium, chloride, and water without having an important effect on glomerular filtration rate, renal plasma flow, or acid-base balance. Wallbank WA. Cardiac effects of halothane and adrenaline in hare-lip and cleft- palate surgery. generic spiriva during pregnancy
The recommended initial dose is 5 mg once daily. If the 5 mg dose does not provide adequate reduction in blood pressure within 4 to 6 weeks, increase to 10 mg once daily. If the response to 10 mg is insufficient, add another antihypertensive agent to the treatment regimen. Increases in total plasma cholesterol concentrations may occur; usually subside during chronic therapy. If you have any signs of side effects from your medicine, contact your doctor. Importance of informing patients of other important precautionary information. 1 See Cautions. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. The other loop diuretic, when administered during the first weeks of life, has also been reported to increase the risk of persistent patent ductus arteriosus. The use of Demadex in such patients has not been studied. Avoid eating licorice or Korean ginseng while taking Demadex. No clinically important effects on hemoglobin; hematocrit; WBC, erythrocyte, or platelet counts; or serum alkaline phosphatase concentrations. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Gupta D, Georgiopoulou VV, Kalogeropoulos AP et al. Dietary sodium intake in heart failure. Circulation. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Diabetic patients - Demadex may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. Slight alterations in calcium and magnesium concentrations. Izzo JL, Levy D, Black HR. Importance of systolic blood pressure in older Americans. Hypertension. latisse in thailand
Torsemide is also used alone or together with other medicines to treat high blood pressure hypertension. High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled. Use dopamine as directed by your doctor. Check the label on the medicine for exact dosing instructions. Some of the side effects that can occur with torsemide may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. Hirshom WI, Taylor RG, Sheehan JC. Arrhythmias produced by combinations of halothane and small amounts of vasopressor. Management of hypertension alone or in combination with other classes of antihypertensive agents. tamoxifen
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Seizures reported in patients with acute renal failure receiving higher than recommended dosages of torsemide. In patients with essential hypertension, Demadex has been shown in controlled studies to lower blood pressure when administered once a day at doses of 5 mg to 10 mg. The antihypertensive effect is near maximal after 4 to 6 weeks of treatment, but it may continue to increase for up to 12 weeks. Systolic and diastolic supine and standing blood pressures are all reduced. There is no significant orthostatic effect, and there is only a minimal peak-trough difference in blood pressure reduction.
The presence of other medical problems may affect the use of this medicine. Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in geriatric patients. Jensen ON, Olesen OV. Subnormal serum folate due to anticonvulsive therapy. A double-blind study of the effect of folic acid treatment in patients with drug- induced subnormal serum folates. Smith WB, Ferguson J et al. Pharmacodynamics of torsemide administered as an intravenous injection and as a continuous infusion to patients with congestive heart failure. J Clinical Pharmacol.
In patients with renal failure, renal clearance of torsemide is markedly decreased but total plasma clearance is not significantly altered. A smaller fraction of the administered dose is delivered to the intraluminal site of action, and the natriuretic action of any given dose of diuretic is reduced. When given with aldosterone antagonists, Demadex also caused increases in sodium and fluid excretion in patients with edema or ascites due to hepatic cirrhosis. Urinary sodium excretion rate relative to the urinary excretion rate of Demadex is less in cirrhotic patients than in healthy subjects possibly because of the hyperaldosteronism and resultant sodium retention that are characteristic of portal hypertension and ascites. However, because of the increased renal clearance of Demadex in patients with hepatic cirrhosis, these factors tend to balance each other, and the result is an overall natriuretic response that is similar to that seen in healthy subjects. Chronic use of any diuretic in hepatic disease has not been studied in adequate and well-controlled trials.
In the placebo-controlled hypertension studies excessive urination was dose related; 1% of patients receiving placebo, 4% of those treated with 5 mg of daily Demadex, and 15% of those treated with 10 mg. Excessive urination was generally not reported as an adverse event among patients who received Demadex for cardiac, renal, or hepatic failure. American Regent announces increased production and availability of torsemide injection. Demadex and 3% on placebo. In patients followed for 1 year, there was no progressive change in mean serum potassium levels. In patients with congestive heart failure, hepatic cirrhosis, or renal disease treated with Demadex at doses higher than those studied in United States antihypertensive trials, hypokalemia was observed with greater frequency, in a dose-related manner.